Paraneoplastic cerebellar degeneration and anti-Yo antibodies.
نویسندگان
چکیده
a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain b Laboratorio de Neurología Experimental, Centro de Investigación, Hospital Universitario La Fe; Valencia, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) c Servicio de Neurología, Hospital Santa Maria del Rosell, Cartagena, Murcia, Spain d Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, Spain e E. Fages was working at the Servicio de Neurología, Hospital Universitario la Fe, Valencia, Spain, when this paper was written
منابع مشابه
Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration in a female patient with pleural malignant mesothelioma.
Paraneoplastic cerebellar degeneration is a rare non-metastatic complication of malignancies. It presents with acute or subacute onset of ataxia, dysarthria and intention tremor. Paraneoplastic cerebellar degeneration is most commonly associated with malignancies of the ovary, breast and lung. The anti-Yo (anti-Purkinje cells) antibodies that specifically damage the Purkinje cells of the cerebe...
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Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast malignancies. We have previously demonstrated that incubation of rat cerebellar slice cultures with patient sera and cerebrospinal fluid containing ant...
متن کاملParaneoplastic cerebellar degeneration in patients with breast cancer: two case reports and literature review
Paraneoplastic neurological syndrome (PNS) is a rare immune-mediated syndrome occurring in less than 1-3% of patients with breast cancer. Two rare cases of paraneoplastic cerebellar degeneration with breast carcinoma were reported here with a brief review of the pertinent literature. The primary indications of these two female patients were progressive lower limb weakness and gait ataxia. Both ...
متن کاملOnconeural antibodies with special reference to anti-Yo
..............................................................................................................7 LIST OF PUBLICATIONS.........................................................................................9 ABBREVIATIONS...................................................................................................10 1. THE IMMUNE SYSTEM .........................................
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عنوان ژورنال:
- Neurologia
دوره 26 5 شماره
صفحات -
تاریخ انتشار 2011